# GO NS enrichment name ratio_in_study ratio_in_pop p_uncorrected depth study_count p_fdr_bh study_items GO:0042802 MF e identical protein binding 85/204 1920/19669 1.82605115245142e-33 3 85 8.675569025296697e-30 60, 196, 213, 229, 283, 302, 331, 335, 348, 350, 351, 383, 581, 598, 834, 847, 1401, 1471, 1510, 1610, 1737, 2023, 2043, 2066, 2081, 2130, 2194, 2521, 2670, 2733, 2941, 2944, 2947, 3064, 3075, 3162, 3297, 3654, 3934, 3949, 4137, 4143, 4199, 4217, 4318, 4831, 4851, 4860, 5071, 5091, 5130, 5154, 5444, 5445, 5446, 5468, 5836, 6256, 6622, 6647, 6648, 6652, 7124, 7157, 7276, 7415, 7422, 7431, 7450, 7846, 8878, 9217, 9370, 9782, 10133, 11035, 11315, 23064, 23435, 26061, 29110, 29978, 56893, 57679, 729230 GO:0019899 MF e enzyme binding 67/204 1923/19669 8.133880871326954e-20 3 67 1.9322034009837174e-16 60, 229, 302, 335, 351, 598, 834, 847, 1152, 1191, 1440, 1471, 1571, 1639, 2023, 2043, 2081, 2934, 2944, 2947, 2950, 3064, 3146, 3162, 3297, 3309, 3718, 3727, 3949, 4137, 4217, 4744, 4831, 4851, 5071, 5243, 5465, 5468, 5580, 5591, 5663, 5743, 6256, 6464, 6615, 6647, 6648, 7074, 7114, 7124, 7157, 7277, 7415, 7450, 8878, 9217, 10133, 10891, 11315, 23476, 27040, 29110, 50507, 54209, 57679, 81631, 203228 GO:0005488 MF e binding 202/204 15872/19669 2.1553997910758463e-16 1 202 3.4134348024671163e-13 60, 183, 196, 213, 229, 283, 302, 311, 331, 335, 348, 350, 351, 383, 581, 598, 682, 755, 794, 821, 834, 847, 899, 924, 968, 1152, 1191, 1244, 1270, 1356, 1387, 1401, 1440, 1471, 1509, 1510, 1559, 1571, 1610, 1639, 1719, 1737, 2023, 2043, 2052, 2066, 2081, 2130, 2180, 2194, 2243, 2251, 2326, 2353, 2521, 2554, 2664, 2670, 2733, 2876, 2892, 2896, 2934, 2936, 2941, 2944, 2947, 2950, 3030, 3064, 3075, 3146, 3162, 3178, 3181, 3297, 3309, 3440, 3458, 3479, 3553, 3569, 3627, 3654, 3718, 3727, 3797, 3798, 3934, 3949, 4137, 4143, 4199, 4217, 4313, 4318, 4336, 4524, 4744, 4750, 4780, 4831, 4846, 4851, 4860, 5071, 5091, 5130, 5154, 5166, 5179, 5216, 5243, 5321, 5327, 5444, 5445, 5446, 5465, 5468, 5580, 5591, 5630, 5663, 5743, 5836, 6256, 6311, 6347, 6404, 6464, 6506, 6529, 6615, 6622, 6647, 6648, 6649, 6652, 6696, 6888, 7074, 7090, 7114, 7124, 7157, 7276, 7277, 7415, 7422, 7431, 7450, 7476, 7846, 8148, 8878, 9104, 9118, 9131, 9217, 9370, 9474, 9782, 9896, 9971, 10096, 10133, 10280, 10383, 10736, 10891, 11035, 11315, 23025, 23064, 23256, 23435, 23476, 25978, 26039, 26061, 26762, 27040, 27242, 29110, 29978, 50507, 51163, 54209, 54822, 56893, 57172, 57679, 64283, 80208, 81631, 83667, 136319, 170825, 203228, 400916, 729230 GO:0005515 MF e protein binding 187/204 13658/19669 1.5642479298478936e-14 2 187 1.8579354786768355e-11 60, 183, 196, 213, 229, 283, 302, 311, 331, 335, 348, 350, 351, 383, 581, 598, 682, 755, 821, 834, 847, 899, 924, 968, 1152, 1191, 1244, 1270, 1356, 1387, 1401, 1440, 1471, 1509, 1510, 1571, 1610, 1639, 1737, 2023, 2043, 2052, 2066, 2081, 2130, 2194, 2243, 2251, 2326, 2353, 2521, 2664, 2670, 2733, 2876, 2896, 2934, 2941, 2944, 2947, 2950, 3030, 3064, 3075, 3146, 3162, 3178, 3181, 3297, 3309, 3440, 3458, 3479, 3553, 3569, 3627, 3654, 3718, 3727, 3797, 3798, 3934, 3949, 4137, 4143, 4199, 4217, 4313, 4318, 4336, 4744, 4750, 4780, 4831, 4846, 4851, 4860, 5071, 5091, 5130, 5154, 5166, 5179, 5216, 5243, 5327, 5444, 5445, 5446, 5465, 5468, 5580, 5591, 5630, 5663, 5743, 5836, 6256, 6311, 6347, 6404, 6464, 6506, 6529, 6615, 6622, 6647, 6648, 6649, 6652, 6696, 6888, 7074, 7090, 7114, 7124, 7157, 7276, 7277, 7415, 7422, 7431, 7450, 7476, 7846, 8148, 8878, 9118, 9131, 9217, 9370, 9474, 9782, 9896, 9971, 10096, 10133, 10280, 10383, 10736, 10891, 11035, 11315, 23025, 23064, 23256, 23435, 23476, 25978, 26039, 26061, 27040, 27242, 29110, 29978, 50507, 54209, 54822, 56893, 57172, 57679, 80208, 81631, 83667, 203228, 400916, 729230 GO:0005102 MF e signaling receptor binding 51/204 1553/19669 7.437570418888591e-14 3 51 7.067179412027939e-11 183, 283, 335, 348, 351, 1191, 1270, 1401, 1440, 2043, 2066, 2081, 2243, 2251, 2896, 3146, 3440, 3458, 3479, 3553, 3569, 3627, 3727, 4851, 5071, 5154, 5179, 5327, 5468, 5663, 6256, 6311, 6347, 6404, 6464, 6696, 7074, 7124, 7157, 7276, 7415, 7422, 7450, 7476, 8878, 9370, 9971, 10383, 10891, 11315, 729230 GO:0036094 MF e small molecule binding 61/204 2421/19669 1.829868693214514e-11 2 61 1.4489510269103594e-08 60, 213, 229, 335, 682, 847, 1152, 1244, 1571, 1610, 1719, 2043, 2066, 2081, 2180, 2194, 2326, 2733, 2936, 3309, 3654, 3718, 3797, 3798, 3934, 4143, 4199, 4217, 4524, 4750, 4831, 4846, 4860, 5091, 5166, 5216, 5243, 5468, 5580, 5591, 5836, 6256, 6648, 6652, 6888, 7157, 7277, 7415, 7846, 9131, 9971, 10096, 10383, 11035, 11315, 23064, 26061, 29110, 50507, 54822, 57172 GO:0043167 MF e ion binding 107/204 5919/19669 2.7708863192276663e-11 2 107 1.880640128950092e-08 60, 213, 283, 302, 311, 331, 335, 348, 351, 383, 794, 821, 847, 1152, 1244, 1356, 1387, 1401, 1559, 1571, 1610, 1719, 2023, 2043, 2066, 2081, 2130, 2180, 2243, 2326, 2521, 2733, 2934, 2936, 2944, 2947, 2950, 3162, 3309, 3654, 3718, 3797, 3798, 3934, 3949, 4143, 4199, 4217, 4313, 4318, 4524, 4750, 4831, 4846, 4851, 4860, 5071, 5091, 5130, 5166, 5216, 5243, 5321, 5444, 5445, 5446, 5465, 5468, 5580, 5591, 5743, 5836, 6256, 6506, 6529, 6615, 6622, 6647, 6648, 6649, 6652, 7157, 7277, 7415, 7846, 8148, 8878, 9104, 9131, 9370, 9782, 9971, 10096, 10133, 10383, 11035, 11315, 23025, 23064, 26061, 29110, 50507, 51163, 54822, 57172, 64283, 83667 GO:0003674 MF e molecular_function 204/204 17455/19669 3.605768353001519e-11 0 204 2.1413756806387768e-08 60, 183, 196, 213, 229, 283, 302, 311, 331, 335, 348, 350, 351, 383, 581, 598, 682, 755, 794, 821, 834, 847, 899, 924, 968, 1152, 1191, 1244, 1270, 1356, 1387, 1401, 1440, 1471, 1509, 1510, 1559, 1571, 1610, 1639, 1719, 1737, 1804, 2023, 2043, 2052, 2066, 2081, 2130, 2180, 2194, 2243, 2251, 2326, 2353, 2521, 2554, 2664, 2670, 2733, 2876, 2892, 2896, 2934, 2936, 2941, 2944, 2947, 2950, 3030, 3064, 3075, 3146, 3162, 3178, 3181, 3297, 3309, 3440, 3458, 3479, 3553, 3569, 3627, 3654, 3718, 3727, 3797, 3798, 3934, 3949, 4137, 4143, 4199, 4217, 4313, 4318, 4336, 4524, 4744, 4750, 4780, 4831, 4846, 4851, 4860, 5071, 5091, 5130, 5154, 5166, 5179, 5216, 5243, 5321, 5327, 5444, 5445, 5446, 5465, 5468, 5580, 5591, 5630, 5663, 5743, 5836, 6256, 6311, 6347, 6404, 6464, 6506, 6529, 6615, 6622, 6647, 6648, 6649, 6652, 6696, 6888, 7074, 7090, 7114, 7124, 7157, 7276, 7277, 7415, 7422, 7431, 7450, 7476, 7846, 8148, 8878, 9104, 9118, 9131, 9217, 9370, 9474, 9782, 9896, 9971, 10096, 10133, 10280, 10383, 10736, 10891, 11035, 11315, 23025, 23064, 23256, 23435, 23476, 25978, 26039, 26061, 26762, 27040, 27242, 29110, 29978, 50507, 51163, 54209, 54822, 55830, 56893, 57172, 57679, 64283, 80208, 81631, 83667, 136319, 170825, 203228, 400916, 729230 GO:0043168 MF e anion binding 59/204 2349/19669 5.025347935742462e-11 3 59 2.65282533807916e-08 60, 213, 302, 1152, 1244, 1610, 1719, 2043, 2066, 2081, 2180, 2326, 2733, 2934, 2936, 2944, 2947, 2950, 3309, 3654, 3718, 3797, 3798, 3934, 4143, 4199, 4217, 4524, 4750, 4831, 4846, 4860, 5091, 5166, 5216, 5243, 5321, 5468, 5580, 5591, 5836, 6256, 7157, 7277, 7415, 7846, 9131, 9370, 9971, 10096, 10383, 11035, 23064, 26061, 29110, 50507, 54822, 57172, 83667 GO:0098772 MF e molecular function regulator 58/204 2287/19669 5.804489604095629e-11 1 58 2.757713010905833e-08 183, 302, 331, 335, 348, 350, 351, 834, 899, 1270, 1387, 1440, 1471, 1804, 2130, 2251, 2521, 2664, 2896, 2950, 3146, 3440, 3458, 3479, 3553, 3569, 3627, 3654, 4831, 4851, 5071, 5154, 5179, 5216, 5580, 6347, 6622, 6696, 7074, 7090, 7124, 7157, 7276, 7415, 7422, 7476, 8148, 9104, 9370, 10891, 11035, 11315, 23476, 26039, 57679, 64283, 83667, 203228 GO:0044877 MF e protein-containing complex binding 40/204 1230/19669 8.584594392632798e-11 2 40 3.4629372413477795e-08 60, 196, 311, 335, 348, 1191, 1270, 1401, 2353, 2934, 3146, 3309, 3440, 3479, 3553, 3949, 4137, 4318, 4524, 4744, 4831, 5071, 5154, 5465, 6464, 6622, 6696, 7157, 7276, 7415, 7431, 7450, 8878, 10096, 10736, 11035, 11315, 23256, 23476, 54209 GO:0016209 MF e antioxidant activity 12/204 86/19669 8.746631634639728e-11 1 12 3.4629372413477795e-08 213, 348, 847, 2876, 2936, 2950, 5743, 6647, 6648, 6649, 11315, 83667 GO:0030546 MF e signaling receptor activator activity 23/204 489/19669 1.6439053447502562e-09 3 23 6.007841763775745e-07 183, 335, 351, 1270, 1440, 2251, 2896, 3146, 3440, 3458, 3479, 3553, 3569, 3627, 5154, 5179, 6347, 6696, 7124, 7276, 7422, 7476, 9370 GO:0070851 MF e growth factor receptor binding 13/204 141/19669 2.7056523884430076e-09 4 13 9.181824641066236e-07 351, 1270, 1440, 2066, 2081, 2251, 3553, 3569, 5154, 5663, 6311, 6464, 7422 GO:0031072 MF e heat shock protein binding 12/204 119/19669 4.026661932764594e-09 3 12 1.2753780561709729e-06 196, 335, 581, 1571, 2081, 3064, 3297, 3309, 3654, 4137, 5071, 6622 GO:0048018 MF e receptor ligand activity 22/204 483/19669 6.836029402765288e-09 4 22 1.941976880894668e-06 183, 335, 1270, 1440, 2251, 2896, 3146, 3440, 3458, 3479, 3553, 3569, 3627, 5154, 5179, 6347, 6696, 7124, 7276, 7422, 7476, 9370 GO:0051087 MF e chaperone binding 11/204 100/19669 7.217839578901145e-09 3 11 1.941976880894668e-06 213, 581, 1191, 1356, 2896, 3309, 4137, 5071, 6647, 7157, 7450 GO:0008289 MF e lipid binding 28/204 768/19669 7.357521333635871e-09 2 28 1.941976880894668e-06 213, 302, 311, 335, 348, 350, 581, 2733, 2934, 2950, 3146, 4137, 4831, 5130, 5216, 5321, 5444, 5465, 5468, 6256, 6464, 6622, 7074, 7415, 9971, 23025, 26762, 54209 GO:0030545 MF e receptor regulator activity 23/204 532/19669 8.098196442589757e-09 2 23 2.0249753315128387e-06 183, 335, 351, 1270, 1440, 2251, 2896, 3146, 3440, 3458, 3479, 3553, 3569, 3627, 5154, 5179, 6347, 6696, 7124, 7276, 7422, 7476, 9370 GO:0019904 MF e protein domain specific binding 26/204 684/19669 1.147282386361008e-08 3 26 2.7253693088005747e-06 351, 581, 598, 834, 1244, 2043, 2876, 3178, 3309, 3553, 4137, 4217, 4780, 5071, 5465, 5468, 5591, 5663, 6256, 7157, 7415, 7431, 7846, 8878, 9217, 25978 GO:0016491 MF e oxidoreductase activity 27/204 740/19669 1.3800556189854692e-08 2 27 3.1222115456190305e-06 847, 1356, 1559, 1571, 1610, 1719, 1737, 2194, 2326, 2876, 2936, 2950, 3030, 3162, 4199, 4524, 4846, 5743, 6622, 6647, 6648, 6649, 6652, 9131, 11315, 50507, 83667 GO:0033218 MF e amide binding 19/204 377/19669 1.5550704993321043e-08 2 19 3.358245428330375e-06 283, 335, 348, 847, 1191, 1471, 1719, 2043, 2194, 2892, 2944, 2947, 2950, 3949, 5091, 5321, 5468, 6256, 54209 GO:0005125 MF e cytokine activity 15/204 235/19669 2.490128937728701e-08 5 15 5.143740253543069e-06 1270, 1440, 2896, 3146, 3440, 3458, 3553, 3569, 3627, 6347, 6696, 7124, 7422, 7476, 9370 GO:0072341 MF e modified amino acid binding 10/204 90/19669 3.2128761713268514e-08 2 10 6.360156120822447e-06 302, 1719, 2194, 2944, 2947, 2950, 3146, 4524, 26762, 50507 GO:0005507 MF e copper ion binding 8/204 58/19669 1.4344127016282678e-07 6 8 2.72595789817436e-05 213, 283, 1356, 6622, 6647, 6649, 7157, 11315 GO:0003824 MF e catalytic activity 93/204 5583/19669 1.812421209859137e-07 1 93 3.309952100464205e-05 229, 283, 331, 383, 834, 847, 1152, 1244, 1356, 1387, 1509, 1510, 1559, 1571, 1610, 1639, 1719, 1737, 1804, 2023, 2043, 2052, 2066, 2081, 2180, 2194, 2326, 2876, 2936, 2941, 2944, 2947, 2950, 3030, 3146, 3162, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4313, 4318, 4524, 4750, 4831, 4846, 4860, 5071, 5091, 5130, 5166, 5243, 5321, 5327, 5444, 5445, 5446, 5580, 5591, 5663, 5743, 5836, 6347, 6622, 6647, 6648, 6649, 6652, 6888, 7277, 7415, 7846, 8878, 9104, 9131, 9896, 10383, 11035, 11315, 23064, 23476, 26061, 29110, 50507, 51163, 54822, 55830, 57172, 83667 GO:0008144 MF e drug binding 8/204 60/19669 1.8810504464856567e-07 2 8 3.309952100464205e-05 213, 1719, 2554, 2950, 3934, 4831, 5465, 5836 GO:1901363 MF e heterocyclic compound binding 95/204 5803/19669 2.591606904474428e-07 2 95 4.397401572556431e-05 60, 196, 213, 283, 302, 311, 351, 821, 847, 1152, 1244, 1387, 1559, 1571, 1610, 1719, 2023, 2043, 2066, 2081, 2130, 2180, 2194, 2326, 2353, 2521, 2896, 2936, 3146, 3162, 3178, 3181, 3297, 3309, 3654, 3718, 3727, 3797, 3798, 3934, 4137, 4143, 4199, 4217, 4524, 4750, 4780, 4831, 4846, 4851, 4860, 5091, 5166, 5216, 5243, 5465, 5468, 5580, 5591, 5743, 5836, 6256, 6311, 6615, 6622, 6648, 6652, 7114, 7124, 7157, 7277, 7415, 7431, 7846, 8148, 9131, 9782, 9971, 10096, 10383, 10736, 10891, 11035, 11315, 23064, 23435, 26061, 29110, 50507, 51163, 54822, 57172, 64283, 136319, 170825 GO:0097159 MF e organic cyclic compound binding 96/204 5883/19669 2.824714947505271e-07 2 96 4.62766231572329e-05 60, 196, 213, 283, 302, 311, 335, 351, 821, 847, 1152, 1244, 1387, 1559, 1571, 1610, 1719, 2023, 2043, 2066, 2081, 2130, 2180, 2194, 2326, 2353, 2521, 2896, 2936, 3146, 3162, 3178, 3181, 3297, 3309, 3654, 3718, 3727, 3797, 3798, 3934, 4137, 4143, 4199, 4217, 4524, 4750, 4780, 4831, 4846, 4851, 4860, 5091, 5166, 5216, 5243, 5465, 5468, 5580, 5591, 5743, 5836, 6256, 6311, 6615, 6622, 6648, 6652, 7114, 7124, 7157, 7277, 7415, 7431, 7846, 8148, 9131, 9782, 9971, 10096, 10383, 10736, 10891, 11035, 11315, 23064, 23435, 26061, 29110, 50507, 51163, 54822, 57172, 64283, 136319, 170825 GO:0071814 MF e protein-lipid complex binding 6/204 28/19669 3.601915031653253e-07 3 6 5.5202252630272913e-05 335, 348, 1401, 3949, 4137, 54209 GO:0071813 MF e lipoprotein particle binding 6/204 28/19669 3.601915031653253e-07 4 6 5.5202252630272913e-05 335, 348, 1401, 3949, 4137, 54209 GO:0042803 MF e protein homodimerization activity 23/204 659/19669 3.892183674542998e-07 4 23 5.778676449298057e-05 196, 283, 348, 581, 598, 847, 2023, 2066, 2081, 2941, 2944, 2947, 3162, 3654, 4217, 5154, 5444, 5446, 7422, 9217, 9370, 11315, 57679 GO:0031406 MF e carboxylic acid binding 12/204 183/19669 4.847209030466446e-07 4 12 6.97851215265033e-05 213, 1719, 2950, 4831, 4846, 5091, 5468, 5836, 6256, 9370, 9971, 83667 GO:0097367 MF e carbohydrate derivative binding 48/204 2213/19669 5.514542117321445e-07 2 48 7.705761646880643e-05 60, 283, 348, 350, 351, 1152, 1244, 2043, 2066, 2081, 2180, 3075, 3146, 3309, 3627, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4750, 4831, 4846, 4860, 5091, 5166, 5243, 5580, 5591, 5836, 6649, 7157, 7277, 7415, 7422, 7846, 9370, 10096, 10383, 11035, 23064, 26061, 29110, 54209, 54822, 57172 GO:0042277 MF e peptide binding 15/204 304/19669 7.03385472430585e-07 3 15 9.11037254427045e-05 283, 335, 348, 847, 1191, 1471, 2043, 2892, 2944, 2947, 2950, 3949, 5468, 6256, 54209 GO:0019900 MF e kinase binding 24/204 735/19669 7.061797882827274e-07 4 24 9.11037254427045e-05 60, 598, 834, 1639, 2043, 2934, 2950, 3064, 3297, 4137, 4217, 4744, 5071, 5580, 6464, 6615, 7074, 7157, 7277, 8878, 11315, 27040, 50507, 54209 GO:0033293 MF e monocarboxylic acid binding 8/204 71/19669 7.095007033003718e-07 5 8 9.11037254427045e-05 213, 2950, 4831, 5091, 5468, 5836, 6256, 9971 GO:0000166 MF e nucleotide binding 46/204 2103/19669 9.322362365528076e-07 4 46 0.0001144183397749 60, 847, 1152, 1244, 1610, 1719, 2043, 2066, 2081, 2180, 2326, 2936, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4524, 4750, 4831, 4846, 5091, 5166, 5216, 5243, 5580, 5591, 5836, 6652, 7157, 7277, 7415, 7846, 9131, 10096, 10383, 11035, 23064, 26061, 29110, 50507, 54822, 57172 GO:1901265 MF e nucleoside phosphate binding 46/204 2104/19669 9.392370556139972e-07 3 46 0.0001144183397749 60, 847, 1152, 1244, 1610, 1719, 2043, 2066, 2081, 2180, 2326, 2936, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4524, 4750, 4831, 4846, 5091, 5166, 5216, 5243, 5580, 5591, 5836, 6652, 7157, 7277, 7415, 7846, 9131, 10096, 10383, 11035, 23064, 26061, 29110, 50507, 54822, 57172 GO:0050661 MF e NADP binding 7/204 52/19669 1.0493053758769188e-06 5 7 0.0001214824527772 847, 1719, 2326, 2936, 4199, 4524, 4846 GO:0005543 MF e phospholipid binding 18/204 448/19669 1.0726008791483955e-06 3 18 0.0001214824527772 302, 311, 335, 348, 350, 2733, 2934, 3146, 4137, 5130, 5216, 5321, 5444, 6464, 6622, 23025, 26762, 54209 GO:0046573 MF e lactonohydrolase activity 3/204 3/19669 1.0995044136861876e-06 5 3 0.0001214824527772 5444, 5445, 5446 GO:0102007 MF e acyl-L-homoserine-lactone lactonohydrolase activity 3/204 3/19669 1.0995044136861876e-06 6 3 0.0001214824527772 5444, 5445, 5446 GO:0005200 MF e structural constituent of cytoskeleton 9/204 102/19669 1.15950172527501e-06 2 9 0.0001251998340177 60, 2670, 4744, 7277, 7431, 7846, 9118, 10096, 10383 GO:0001540 MF e amyloid-beta binding 8/204 84/19669 2.591105936566089e-06 4 8 0.0002735632067694 335, 348, 1191, 1471, 2043, 2892, 3949, 54209 GO:1901681 MF e sulfur compound binding 13/204 258/19669 3.144714611036269e-06 2 13 0.0003247943286311 283, 348, 350, 351, 2944, 2947, 2950, 3075, 3627, 5091, 6649, 7422, 26061 GO:0004784 MF e superoxide dismutase activity 3/204 4/19669 4.364304588366984e-06 4 3 0.000431975231236 6647, 6648, 6649 GO:0016721 MF e oxidoreductase activity, acting on superoxide radicals as acceptor 3/204 4/19669 4.364304588366984e-06 3 3 0.000431975231236 6647, 6648, 6649 GO:0046914 MF e transition metal ion binding 28/204 1071/19669 6.200975528172338e-06 5 28 0.0006012415251907 213, 283, 351, 383, 1356, 1387, 1559, 1571, 3934, 4199, 4313, 4318, 4846, 5071, 5465, 5468, 6256, 6622, 6647, 6648, 6649, 6652, 7157, 8878, 9104, 9782, 9971, 11315 GO:0008092 MF e cytoskeletal protein binding 26/204 967/19669 8.415314001444434e-06 3 26 0.0007996231364172 60, 229, 283, 302, 348, 1191, 1639, 2934, 3064, 3797, 3798, 4137, 4336, 4744, 4846, 5071, 5216, 5468, 6622, 7074, 7114, 9217, 10096, 10891, 54822, 81631 GO:0002020 MF e protease binding 9/204 130/19669 8.683284841719017e-06 4 9 0.0008089075741766 302, 1471, 3949, 5071, 7124, 7157, 7415, 7450, 11315 GO:0140297 MF e DNA-binding transcription factor binding 15/204 375/19669 9.2072828766387e-06 4 15 0.0008412269412867 60, 1387, 2353, 3146, 3297, 3727, 4780, 5465, 5468, 6256, 7090, 7157, 9971, 10891, 11315 GO:0050660 MF e flavin adenine dinucleotide binding 7/204 81/19669 2.1159257960613623e-05 5 7 0.0018905896423772 1610, 2326, 2936, 4524, 4846, 9131, 50507 GO:0004064 MF e arylesterase activity 3/204 6/19669 2.148849519856249e-05 5 3 0.0018905896423772 5444, 5445, 5446 GO:0004672 MF e protein kinase activity 18/204 560/19669 2.310185006604957e-05 5 18 0.0019955798120691 2043, 2066, 2081, 3654, 3718, 4217, 4750, 4831, 5166, 5580, 5591, 6347, 8878, 11035, 23476, 29110, 54822, 57172 GO:0046983 MF e protein dimerization activity 26/204 1027/19669 2.387695291480319e-05 3 26 0.0020257036303255 196, 283, 348, 581, 598, 847, 2023, 2066, 2081, 2941, 2944, 2947, 3162, 3297, 3654, 4217, 5154, 5444, 5446, 7157, 7422, 9131, 9217, 9370, 11315, 57679 GO:0030234 MF e enzyme regulator activity 29/204 1212/19669 2.4359869133344835e-05 2 29 0.0020304164605705 183, 302, 331, 335, 348, 350, 351, 834, 899, 1471, 2664, 2950, 3146, 3627, 3654, 4851, 5216, 5580, 6622, 7074, 7157, 7415, 9104, 11035, 11315, 57679, 64283, 83667, 203228 GO:0005126 MF e cytokine receptor binding 12/204 270/19669 2.652744749198918e-05 4 12 0.0021729638454213 1270, 1440, 3440, 3458, 3553, 3569, 3627, 6347, 6464, 7124, 7422, 729230 GO:0016684 MF e oxidoreductase activity, acting on peroxide as acceptor 6/204 57/19669 2.7017542440897483e-05 3 6 0.0021755990531644 847, 2876, 2950, 5743, 11315, 83667 GO:0061629 MF e RNA polymerase II-specific DNA-binding transcription factor binding 12/204 271/19669 2.7507383912106664e-05 5 12 0.0021781263494403 60, 1387, 2353, 3297, 3727, 4780, 5465, 5468, 6256, 9971, 10891, 11315 GO:0043169 MF e cation binding 70/204 4263/19669 3.475609796876232e-05 3 70 0.0027069872368785 213, 283, 302, 311, 331, 335, 348, 351, 383, 794, 821, 847, 1356, 1387, 1401, 1559, 1571, 2023, 2081, 2130, 2243, 2521, 2934, 3162, 3309, 3934, 3949, 4143, 4199, 4217, 4313, 4318, 4750, 4831, 4846, 4851, 5071, 5091, 5130, 5321, 5444, 5445, 5446, 5465, 5468, 5580, 5743, 5836, 6256, 6506, 6529, 6615, 6622, 6647, 6648, 6649, 6652, 7157, 8148, 8878, 9104, 9782, 9971, 10133, 11315, 23025, 26061, 51163, 54822, 64283 GO:0019825 MF e oxygen binding 5/204 38/19669 4.341984019248369e-05 3 5 0.0033272203347498 213, 1571, 6648, 11315, 50507 GO:0008083 MF e growth factor activity 9/204 161/19669 4.7744713396178254e-05 5 9 0.0036005576721467 183, 1270, 1440, 2251, 2896, 3479, 3569, 5154, 7422 GO:0030544 MF e Hsp70 protein binding 5/204 39/19669 4.93879567918311e-05 4 5 0.0036662841049685 581, 1571, 2081, 5071, 6622 GO:0019901 MF e protein kinase binding 19/204 654/19669 5.39071853498728e-05 5 19 0.0039402005784191 60, 598, 1639, 2043, 2950, 3297, 4137, 4217, 4744, 5071, 5580, 6464, 7074, 7157, 7277, 8878, 27040, 50507, 54209 GO:0030554 MF e adenyl nucleotide binding 33/204 1529/19669 5.595955107237055e-05 6 33 0.0039689093334594 60, 1152, 1244, 2043, 2066, 2081, 2180, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4750, 4831, 5091, 5166, 5216, 5243, 5580, 5591, 5836, 7157, 7415, 10096, 11035, 23064, 26061, 29110, 54822, 57172 GO:0051879 MF e Hsp90 protein binding 5/204 40/19669 5.597072728726166e-05 4 5 0.0039689093334594 196, 1571, 2081, 3297, 4137 GO:1990782 MF e protein tyrosine kinase binding 7/204 98/19669 7.257437429856411e-05 6 7 0.005070600769007 2043, 6464, 7074, 7157, 8878, 50507, 54209 GO:0099186 MF e structural constituent of postsynapse 3/204 9/19669 8.819596329480058e-05 3 3 0.0060624692842642 60, 4744, 9118 GO:0048156 MF e tau protein binding 5/204 44/19669 8.932284780014681e-05 4 5 0.0060624692842642 60, 348, 1191, 1639, 6622 GO:0046872 MF e metal ion binding 67/204 4177/19669 9.925071229499904e-05 4 67 0.0066414103396273 213, 283, 302, 311, 331, 348, 351, 383, 794, 821, 847, 1356, 1387, 1401, 1559, 1571, 2023, 2081, 2130, 2243, 2521, 2934, 3162, 3309, 3934, 3949, 4143, 4199, 4217, 4313, 4318, 4750, 4831, 4846, 4851, 5071, 5091, 5321, 5444, 5445, 5446, 5465, 5468, 5580, 5743, 6256, 6506, 6529, 6615, 6622, 6647, 6648, 6649, 6652, 7157, 8148, 8878, 9104, 9782, 9971, 10133, 11315, 23025, 26061, 51163, 54822, 64283 GO:0032559 MF e adenyl ribonucleotide binding 32/204 1516/19669 0.0001035456095969 7 32 0.00670421914078 60, 1152, 1244, 2043, 2066, 2081, 2180, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4750, 4831, 5091, 5166, 5243, 5580, 5591, 5836, 7157, 7415, 10096, 11035, 23064, 26061, 29110, 54822, 57172 GO:1903981 MF e enterobactin binding 2/204 2/19669 0.0001070492737825 4 2 0.00670421914078 213, 3934 GO:0016418 MF e S-acetyltransferase activity 2/204 2/19669 0.0001070492737825 6 2 0.00670421914078 1737, 2194 GO:0004063 MF e aryldialkylphosphatase activity 2/204 2/19669 0.0001070492737825 6 2 0.00670421914078 5444, 5446 GO:0008134 MF e transcription factor binding 18/204 631/19669 0.0001072449283728 3 18 0.00670421914078 60, 196, 1387, 2353, 3146, 3297, 3727, 4780, 5465, 5468, 5591, 6256, 7090, 7157, 9971, 10736, 10891, 11315 GO:0005524 MF e ATP binding 31/204 1455/19669 0.0001227869870816 8 31 0.0075761165665593 60, 1152, 1244, 2043, 2066, 2081, 2180, 3309, 3654, 3718, 3797, 3798, 4143, 4217, 4750, 4831, 5091, 5166, 5243, 5580, 5591, 5836, 7157, 7415, 10096, 11035, 23064, 26061, 29110, 54822, 57172 GO:0004364 MF e glutathione transferase activity 4/204 26/19669 0.0001404469929009 4 4 0.008554662349649 2941, 2944, 2947, 2950 GO:0019903 MF e protein phosphatase binding 8/204 148/19669 0.0001591058199609 5 8 0.0095685031725889 3718, 4137, 4217, 5468, 6647, 7157, 7415, 29110 GO:0050839 MF e cell adhesion molecule binding 16/204 540/19669 0.0001701973126548 3 16 0.0101075929052872 302, 682, 2023, 2194, 2243, 3146, 3309, 3479, 3553, 5216, 5663, 6696, 7450, 9217, 11315, 25978 GO:0031593 MF e polyubiquitin modification-dependent protein binding 5/204 51/19669 0.0001821814895344 4 5 0.010685731565162 7415, 8878, 10133, 29978, 56893 GO:0070325 MF e lipoprotein particle receptor binding 4/204 28/19669 0.0001892554300059 4 4 0.0108480801338975 335, 348, 1191, 1401 GO:0019902 MF e phosphatase binding 9/204 193/19669 0.0001908724184847 4 9 0.0108480801338975 3718, 4137, 4217, 5465, 5468, 6647, 7157, 7415, 29110 GO:0016301 MF e kinase activity 19/204 721/19669 0.0001917993540828 4 19 0.0108480801338975 1152, 2043, 2066, 2081, 3654, 3718, 4217, 4750, 4831, 5166, 5580, 5591, 6347, 8878, 11035, 23476, 29110, 54822, 57172 GO:0016773 MF e phosphotransferase activity, alcohol group as acceptor 18/204 662/19669 0.0001941062829715 4 18 0.0108493994164447 2043, 2066, 2081, 3654, 3718, 4217, 4750, 4831, 5166, 5580, 5591, 6347, 8878, 11035, 23476, 29110, 54822, 57172 GO:0098531 MF e ligand-activated transcription factor activity 5/204 52/19669 0.0001998790876467 3 5 0.0109152361541344 196, 5465, 5468, 6256, 9971 GO:0004879 MF e nuclear receptor activity 5/204 52/19669 0.0001998790876467 4 5 0.0109152361541344 196, 5465, 5468, 6256, 9971 GO:0043295 MF e glutathione binding 3/204 12/19669 0.000225735565205 5 3 0.0121871553441955 2944, 2947, 2950 GO:0017076 MF e purine nucleotide binding 36/204 1874/19669 0.0002704069515259 5 36 0.0143638128456238 60, 1152, 1244, 2043, 2066, 2081, 2180, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4750, 4831, 5091, 5166, 5216, 5243, 5580, 5591, 5836, 7157, 7277, 7415, 7846, 10096, 10383, 11035, 23064, 26061, 29110, 54822, 57172 GO:0032553 MF e ribonucleotide binding 36/204 1875/19669 0.0002720991698813 5 36 0.0143638128456238 60, 1152, 1244, 2043, 2066, 2081, 2180, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4750, 4831, 4846, 5091, 5166, 5243, 5580, 5591, 5836, 7157, 7277, 7415, 7846, 10096, 10383, 11035, 23064, 26061, 29110, 54822, 57172 GO:1900750 MF e oligopeptide binding 3/204 13/19669 0.0002912164259789 4 3 0.0152040575805074 2944, 2947, 2950 GO:0016765 MF e transferase activity, transferring alkyl or aryl (other than methyl) groups 5/204 57/19669 0.0003088034581511 3 5 0.0158500324916618 2941, 2944, 2947, 2950, 4143 GO:0099184 MF e structural constituent of postsynaptic intermediate filament cytoskeleton 2/204 3/19669 0.0003189488125109 4 2 0.0158500324916618 4744, 9118 GO:0002060 MF e purine nucleobase binding 2/204 3/19669 0.0003189488125109 4 2 0.0158500324916618 4860, 5836 GO:0050692 MF e DNA binding domain binding 2/204 3/19669 0.0003189488125109 4 2 0.0158500324916618 5468, 6256 GO:0008201 MF e heparin binding 8/204 164/19669 0.0003202700735002 4 8 0.0158500324916618 283, 348, 350, 351, 3075, 3627, 6649, 7422 GO:0098847 MF e sequence-specific single stranded DNA binding 3/204 14/19669 0.0003678115526197 6 3 0.0180151823350149 3178, 3181, 3297 GO:0003713 MF e transcription coactivator activity 10/204 259/19669 0.0003883319021356 3 10 0.0188261721127208 1387, 2521, 3146, 4831, 4851, 10891, 11035, 11315, 23476, 26039 GO:0015631 MF e tubulin binding 12/204 363/19669 0.0004270680465383 4 12 0.020494952415188 1639, 3064, 3797, 3798, 4137, 4744, 5071, 6622, 7074, 9217, 10891, 81631 GO:0005161 MF e platelet-derived growth factor receptor binding 3/204 15/19669 0.0004562586920958 5 3 0.021462228179677 2081, 5154, 7422 GO:0098918 MF e structural constituent of synapse 3/204 15/19669 0.0004562586920958 2 3 0.021462228179677 60, 4744, 9118 GO:0003712 MF e transcription coregulator activity 14/204 481/19669 0.0005188266243905 2 14 0.0239804288872036 1387, 2130, 2521, 3146, 4831, 4851, 5071, 7090, 8148, 10891, 11035, 11315, 23476, 26039 GO:0016922 MF e nuclear receptor binding 6/204 97/19669 0.0005220533705459 7 6 0.0239804288872036 3727, 5468, 6256, 9971, 10891, 11315 GO:0035639 MF e purine ribonucleoside triphosphate binding 34/204 1791/19669 0.0005249346672846 4 34 0.0239804288872036 60, 1152, 1244, 2043, 2066, 2081, 2180, 3309, 3654, 3718, 3797, 3798, 4143, 4217, 4750, 4831, 5091, 5166, 5243, 5580, 5591, 5836, 7157, 7277, 7415, 7846, 10096, 10383, 11035, 23064, 26061, 29110, 54822, 57172 GO:0004674 MF e protein serine/threonine kinase activity 13/204 427/19669 0.0005402181421367 6 13 0.0244435846980181 2081, 3654, 4217, 4750, 4831, 5580, 5591, 8878, 11035, 23476, 29110, 54822, 57172 GO:0005504 MF e fatty acid binding 4/204 37/19669 0.000567557115884 6 4 0.0254383382789161 213, 2950, 4831, 5468 GO:0020037 MF e heme binding 7/204 138/19669 0.0006001879543274 4 7 0.0266494670187814 847, 1559, 1571, 3162, 4846, 5743, 50507 GO:0005539 MF e glycosaminoglycan binding 9/204 227/19669 0.0006261023167023 3 9 0.0271163676162715 283, 348, 350, 351, 3075, 3627, 6649, 7422, 54209 GO:0032555 MF e purine ribonucleotide binding 35/204 1859/19669 0.0006324837027304 6 35 0.0271163676162715 60, 1152, 1244, 2043, 2066, 2081, 2180, 3309, 3654, 3718, 3797, 3798, 4143, 4199, 4217, 4750, 4831, 5091, 5166, 5243, 5580, 5591, 5836, 7157, 7277, 7415, 7846, 10096, 10383, 11035, 23064, 26061, 29110, 54822, 57172 GO:0098973 MF e structural constituent of postsynaptic actin cytoskeleton 2/204 4/19669 0.000633533320439 4 2 0.0271163676162715 60, 9118 GO:0019826 MF e oxygen sensor activity 2/204 4/19669 0.000633533320439 4 2 0.0271163676162715 11315, 50507 GO:0005198 MF e structural molecule activity 17/204 672/19669 0.000663544599332 1 17 0.0281473249234533 60, 348, 2243, 2670, 3162, 4336, 4744, 5630, 7277, 7431, 7450, 7846, 9118, 9370, 9782, 10096, 10383 GO:0030169 MF e low-density lipoprotein particle binding 3/204 17/19669 0.0006715295040244 5 3 0.028233952863895 1401, 3949, 54209 GO:0016772 MF e transferase activity, transferring phosphorus-containing groups 20/204 866/19669 0.0008049898698278 3 20 0.0335483058908093 1152, 2043, 2066, 2081, 3654, 3718, 4217, 4750, 4831, 5130, 5166, 5580, 5591, 6347, 8878, 11035, 23476, 29110, 54822, 57172 GO:0070491 MF e repressing transcription factor binding 5/204 71/19669 0.0008541383447315 5 5 0.0352870545723446 3146, 5465, 5468, 7090, 11315 GO:0046906 MF e tetrapyrrole binding 7/204 148/19669 0.0009076473155558 3 7 0.0371744172086713 847, 1559, 1571, 3162, 4846, 5743, 50507 GO:0031625 MF e ubiquitin protein ligase binding 10/204 290/19669 0.0009302306801557 5 10 0.037764477450933 1152, 1191, 3309, 5071, 5243, 7157, 7415, 8878, 10891, 81631 GO:0016829 MF e lyase activity 8/204 193/19669 0.0009379516605367 2 8 0.037764477450933 229, 2023, 2194, 3030, 3146, 4199, 11315, 26061 GO:0002054 MF e nucleobase binding 2/204 5/19669 0.0010486707576913 3 2 0.0418675190738777 4860, 5836 GO:0043177 MF e organic acid binding 6/204 113/19669 0.001164379233007 3 6 0.0460997144668046 1719, 4846, 5091, 5468, 6256, 9971 GO:0140272 MF e exogenous protein binding 5/204 77/19669 0.0012328724831134 2 5 0.0484080757625773 213, 682, 3949, 6404, 26762 GO:1990381 MF e ubiquitin-specific protease binding 3/204 21/19669 0.0012739146382379 5 3 0.0496095774284303 5071, 7415, 11315 GO:0044389 MF e ubiquitin-like protein ligase binding 10/204 308/19669 0.0014610559097113 4 10 0.0564347693255156 1152, 1191, 3309, 5071, 5243, 7157, 7415, 8878, 10891, 81631 GO:0016709 MF e oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/204 48/19669 0.0015300468400841 4 4 0.0579867674562212 1559, 1571, 2326, 4846 GO:0004704 MF e NF-kappaB-inducing kinase activity 2/204 6/19669 0.0015622618889489 3 2 0.0579867674562212 3654, 11035 GO:0051434 MF e BH3 domain binding 2/204 6/19669 0.0015622618889489 5 2 0.0579867674562212 581, 598 GO:0031727 MF e CCR2 chemokine receptor binding 2/204 6/19669 0.0015622618889489 7 2 0.0579867674562212 6347, 729230 GO:0060228 MF e phosphatidylcholine-sterol O-acyltransferase activator activity 2/204 6/19669 0.0015622618889489 4 2 0.0579867674562212 335, 348 GO:0050750 MF e low-density lipoprotein particle receptor binding 3/204 23/19669 0.0016706419072281 5 3 0.0615288348933409 348, 1191, 1401 GO:0004190 MF e aspartic-type endopeptidase activity 3/204 24/19669 0.0018948108348403 5 3 0.0692480482794357 1509, 1510, 5663 GO:0051219 MF e phosphoprotein binding 5/204 87/19669 0.002121418784057 3 5 0.0758846431510271 5216, 5327, 6464, 6622, 29110 GO:0070001 MF e aspartic-type peptidase activity 3/204 25/19669 0.002136856636647 4 3 0.0758846431510271 1509, 1510, 5663 GO:1903136 MF e cuprous ion binding 2/204 7/19669 0.0021722398376214 7 2 0.0758846431510271 6622, 11315 GO:0005138 MF e interleukin-6 receptor binding 2/204 7/19669 0.0021722398376214 5 2 0.0758846431510271 1270, 3569 GO:0016775 MF e phosphotransferase activity, nitrogenous group as acceptor 2/204 7/19669 0.0021722398376214 4 2 0.0758846431510271 1152, 4831 GO:0050693 MF e LBD domain binding 2/204 7/19669 0.0021722398376214 4 2 0.0758846431510271 5468, 6256 GO:0004601 MF e peroxidase activity 4/204 53/19669 0.0022117329367707 4 4 0.0767003152014435 847, 2876, 2950, 5743 GO:0061134 MF e peptidase regulator activity 8/204 223/19669 0.0023382511881112 3 8 0.0805002274979449 183, 302, 331, 351, 834, 1471, 6622, 7415 GO:0045296 MF e cadherin binding 10/204 332/19669 0.0025277215715129 4 10 0.0863971596133679 302, 682, 2023, 2194, 3309, 5216, 5663, 9217, 11315, 25978 GO:0097371 MF e MDM2/MDM4 family protein binding 2/204 8/19669 0.0028765696463776 3 2 0.0962435379573265 5465, 7157 GO:0036435 MF e K48-linked polyubiquitin modification-dependent protein binding 2/204 8/19669 0.0028765696463776 5 2 0.0962435379573265 7415, 56893 GO:0016174 MF e NAD(P)H oxidase H2O2-forming activity 2/204 8/19669 0.0028765696463776 5 2 0.0962435379573265 9131, 50507 GO:0003785 MF e actin monomer binding 3/204 28/19669 0.0029749386736634 5 3 0.0988386967732521 4846, 5216, 7114 GO:0003723 MF e RNA binding 30/204 1652/19669 0.0031237158779123 4 30 0.1030609314997332 283, 302, 311, 821, 1719, 2023, 2130, 2194, 2521, 2896, 3146, 3178, 3181, 4137, 5216, 5591, 6311, 7114, 7157, 7415, 7431, 8148, 9782, 10383, 10891, 11315, 23064, 23435, 51163, 64283 GO:0035257 MF e nuclear hormone receptor binding 6/204 140/19669 0.0034366628816898 6 6 0.1126040369028176 3727, 5468, 6256, 9971, 10891, 11315 GO:0019842 MF e vitamin binding 6/204 143/19669 0.003813637427935 3 6 0.1240999412336951 213, 1719, 2194, 5091, 5836, 26061 GO:0035198 MF e miRNA binding 3/204 31/19669 0.0039899314280841 6 3 0.1289534980600525 3178, 3181, 9782 GO:0031490 MF e chromatin DNA binding 5/204 102/19669 0.0042221467423936 5 5 0.1355366160345421 60, 1387, 3297, 4851, 10891 GO:0016836 MF e hydro-lyase activity 4/204 64/19669 0.0043933890190527 4 4 0.1400871894598634 2023, 2194, 3030, 11315 GO:0106310 MF e protein serine kinase activity 8/204 248/19669 0.0044567738999427 7 8 0.1406882780947132 2081, 3654, 4750, 5580, 5591, 11035, 29110, 54822 GO:0008035 MF e high-density lipoprotein particle binding 2/204 10/19669 0.0045603020051748 5 2 0.1406882780947132 335, 54209 GO:0098505 MF e G-rich strand telomeric DNA binding 2/204 10/19669 0.0045603020051748 8 2 0.1406882780947132 3178, 3181 GO:0051400 MF e BH domain binding 2/204 10/19669 0.0045603020051748 4 2 0.1406882780947132 581, 598 GO:0001094 MF e TFIID-class transcription factor complex binding 2/204 10/19669 0.0045603020051748 6 2 0.1406882780947132 196, 7157 GO:0005154 MF e epidermal growth factor receptor binding 3/204 33/19669 0.0047700130781752 5 3 0.1452713598359659 2066, 6311, 6464 GO:0071949 MF e FAD binding 3/204 33/19669 0.0047700130781752 6 3 0.1452713598359659 1610, 4524, 9131 GO:0002039 MF e p53 binding 4/204 66/19669 0.0049043034462816 3 4 0.1484098450527641 1387, 3064, 7157, 23476 GO:0048029 MF e monosaccharide binding 4/204 67/19669 0.0051740946039417 3 4 0.155583059894476 229, 682, 5836, 6888 GO:0070513 MF e death domain binding 2/204 11/19669 0.0055357903518382 4 2 0.1623490121085391 581, 598 GO:0008559 MF e ABC-type xenobiotic transporter activity 2/204 11/19669 0.0055357903518382 10 2 0.1623490121085391 1244, 5243 GO:0140299 MF e small molecule sensor activity 2/204 11/19669 0.0055357903518382 1 2 0.1623490121085391 11315, 50507 GO:0032052 MF e bile acid binding 2/204 11/19669 0.0055357903518382 6 2 0.1623490121085391 5836, 9971 GO:0051082 MF e unfolded protein binding 5/204 110/19669 0.0058066157397628 3 5 0.1692468182798355 821, 1191, 2081, 3309, 10383 GO:0140030 MF e modification-dependent protein binding 6/204 157/19669 0.0059898289293497 3 6 0.1735224222154918 7415, 8878, 10133, 23476, 29978, 56893 GO:0003779 MF e actin binding 11/204 437/19669 0.0060826288314624 4 11 0.1746414120251852 283, 2934, 4137, 4336, 4846, 5071, 5216, 6622, 7114, 10096, 54822 GO:0036002 MF e pre-mRNA binding 3/204 36/19669 0.0061019731416924 5 3 0.1746414120251852 3178, 3181, 23435 GO:0003697 MF e single-stranded DNA binding 5/204 113/19669 0.0064962005302396 5 5 0.1811916417353281 3146, 3178, 3181, 3297, 4137 GO:0016705 MF e oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 6/204 160/19669 0.0065542320690782 3 6 0.1811916417353281 1559, 1571, 2326, 3162, 4846, 5743 GO:0042056 MF e chemoattractant activity 3/204 37/19669 0.0065903039678351 5 3 0.1811916417353281 3146, 3627, 7422 GO:0005527 MF e macrolide binding 2/204 12/19669 0.0065978013092426 3 2 0.1811916417353281 213, 3934 GO:0043047 MF e single-stranded telomeric DNA binding 2/204 12/19669 0.0065978013092426 7 2 0.1811916417353281 3178, 3181 GO:0097157 MF e pre-mRNA intronic binding 2/204 12/19669 0.0065978013092426 6 2 0.1811916417353281 3181, 23435 GO:0034452 MF e dynactin binding 2/204 12/19669 0.0065978013092426 4 2 0.1811916417353281 3064, 4137 GO:0030971 MF e receptor tyrosine kinase binding 4/204 72/19669 0.0066725604943516 7 4 0.1821915799348543 6464, 7074, 7157, 8878 GO:0008017 MF e microtubule binding 8/204 267/19669 0.0068755416184443 5 8 0.186661132738452 1639, 3797, 3798, 4137, 4744, 7074, 9217, 81631 GO:0043028 MF e cysteine-type endopeptidase regulator activity involved in apoptotic process 3/204 38/19669 0.007101253993968 3 3 0.1907066928531545 331, 834, 6622 GO:0016740 MF e transferase activity 36/204 2218/19669 0.0071048378520329 2 36 0.1907066928531545 331, 1152, 1387, 1737, 2043, 2066, 2081, 2194, 2941, 2944, 2947, 2950, 3030, 3654, 3718, 4143, 4217, 4750, 4831, 4860, 5071, 5130, 5166, 5321, 5580, 5591, 5836, 6347, 6888, 8878, 11035, 23476, 29110, 54822, 55830, 57172 GO:0019894 MF e kinesin binding 3/204 39/19669 0.0076350679203778 4 3 0.2015233760539731 60, 4744, 6622 GO:0043531 MF e ADP binding 3/204 39/19669 0.0076350679203778 8 3 0.2015233760539731 2081, 4199, 7415 GO:0044390 MF e ubiquitin-like protein conjugating enzyme binding 3/204 39/19669 0.0076350679203778 4 3 0.2015233760539731 5071, 5465, 11315 GO:0001618 MF e virus receptor activity 4/204 76/19669 0.0080595716199853 3 4 0.2115526230196155 682, 3949, 6404, 26762 GO:0005179 MF e hormone activity 5/204 120/19669 0.0083248877775842 5 5 0.2123953148819704 183, 3479, 5179, 7276, 9370 GO:0033613 MF e activating transcription factor binding 4/204 78/19669 0.0088188944966573 5 4 0.2123953148819704 1387, 2353, 4780, 5468 GO:0044548 MF e S100 protein binding 2/204 14/19669 0.008973893364858 3 2 0.2123953148819704 302, 311 GO:0016835 MF e carbon-oxygen lyase activity 4/204 79/19669 0.0092154716318465 3 4 0.2123953148819704 2023, 2194, 3030, 11315 GO:0016504 MF e peptidase activator activity 3/204 42/19669 0.0093759142842584 4 3 0.2123953148819704 351, 834, 7415 GO:0061980 MF e regulatory RNA binding 3/204 42/19669 0.0093759142842584 5 3 0.2123953148819704 3178, 3181, 9782 GO:0051427 MF e hormone receptor binding 6/204 173/19669 0.0094530019542803 4 6 0.2123953148819704 3727, 5468, 6256, 9971, 10891, 11315 GO:0004866 MF e endopeptidase inhibitor activity 6/204 175/19669 0.0099688136663686 5 6 0.2123953148819704 183, 302, 331, 351, 1471, 6622 GO:0005283 MF e amino acid:sodium symporter activity 2/204 15/19669 0.0102842986996421 10 2 0.2123953148819704 6506, 6529 GO:0019215 MF e intermediate filament binding 2/204 15/19669 0.0102842986996421 3 2 0.2123953148819704 4831, 7431 GO:0140161 MF e monocarboxylate:sodium symporter activity 2/204 15/19669 0.0102842986996421 10 2 0.2123953148819704 6506, 6529 GO:0008392 MF e arachidonic acid epoxygenase activity 2/204 15/19669 0.0102842986996421 5 2 0.2123953148819704 1559, 1571 GO:0030414 MF e peptidase inhibitor activity 6/204 181/19669 0.0116362275455192 4 6 0.2350109189722649 183, 302, 331, 351, 1471, 6622 GO:0005159 MF e insulin-like growth factor receptor binding 2/204 16/19669 0.0116738743164501 4 2 0.2350109189722649 3479, 6464 GO:0050664 MF e oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/204 16/19669 0.0116738743164501 4 2 0.2350109189722649 9131, 50507 GO:0005092 MF e GDP-dissociation inhibitor activity 2/204 16/19669 0.0116738743164501 5 2 0.2350109189722649 2664, 83667 GO:0008270 MF e zinc ion binding 16/204 810/19669 0.0122447386300939 6 16 0.2454630938041201 213, 1387, 4313, 4318, 5071, 5465, 5468, 6256, 6622, 6647, 6652, 7157, 8878, 9104, 9782, 9971 GO:0070888 MF e E-box binding 3/204 47/19669 0.0127531931186009 10 3 0.2545815987666944 196, 5468, 6615 GO:0034185 MF e apolipoprotein binding 2/204 17/19669 0.0131408536241348 3 2 0.2579842792077056 4137, 54209 GO:0046965 MF e retinoid X receptor binding 2/204 17/19669 0.0131408536241348 8 2 0.2579842792077056 5468, 9971 GO:0055102 MF e lipase inhibitor activity 2/204 17/19669 0.0131408536241348 4 2 0.2579842792077056 302, 335 GO:0043395 MF e heparan sulfate proteoglycan binding 2/204 17/19669 0.0131408536241348 4 2 0.2579842792077056 348, 3075 GO:0004713 MF e protein tyrosine kinase activity 5/204 135/19669 0.0133856435845535 6 5 0.2607527034106816 2043, 2066, 3718, 4750, 5580 GO:0003676 MF e nucleic acid binding 55/204 3914/19669 0.0134556686219421 3 55 0.2607527034106816 60, 196, 213, 283, 302, 311, 351, 821, 1387, 1719, 2023, 2066, 2130, 2194, 2353, 2521, 2896, 3146, 3178, 3181, 3297, 3727, 4137, 4780, 4831, 4851, 5216, 5465, 5468, 5591, 6256, 6311, 6615, 6622, 6648, 7114, 7124, 7157, 7415, 7431, 8148, 9131, 9782, 9971, 10383, 10736, 10891, 11315, 23064, 23435, 29110, 51163, 64283, 136319, 170825 GO:0061135 MF e endopeptidase regulator activity 6/204 187/19669 0.0134915553400547 4 6 0.2607527034106816 183, 302, 331, 351, 1471, 6622 GO:0001102 MF e RNA polymerase II activating transcription factor binding 3/204 48/19669 0.0135014028707698 6 3 0.2607527034106816 1387, 2353, 4780 GO:0015355 MF e secondary active monocarboxylate transmembrane transporter activity 2/204 18/19669 0.0146834978472462 8 2 0.2812955575494634 6506, 6529 GO:0016646 MF e oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/204 18/19669 0.0146834978472462 4 2 0.2812955575494634 1719, 4524 GO:0106311 MF e protein threonine kinase activity 7/204 247/19669 0.0148064308979816 7 7 0.2825114586197226 2081, 3654, 4750, 5591, 11035, 29110, 54822 GO:0016830 MF e carbon-carbon lyase activity 3/204 50/19669 0.0150715173980383 3 3 0.2864191166323201 229, 4199, 26061 GO:0052689 MF e carboxylic ester hydrolase activity 5/204 141/19669 0.0158883434525367 4 5 0.3007391224820791 5321, 5444, 5445, 5446, 9104 GO:0001091 MF e RNA polymerase II general transcription initiation factor binding 2/204 19/19669 0.0163000956404128 5 2 0.3043198228953414 196, 7157 GO:0008391 MF e arachidonic acid monooxygenase activity 2/204 19/19669 0.0163000956404128 4 2 0.3043198228953414 1559, 1571 GO:0005416 MF e amino acid:cation symporter activity 2/204 19/19669 0.0163000956404128 8 2 0.3043198228953414 6506, 6529 GO:0005178 MF e integrin binding 5/204 142/19669 0.0163337307594847 4 5 0.3043198228953414 3146, 3479, 3553, 6696, 7450 GO:0016407 MF e acetyltransferase activity 4/204 95/19669 0.0171944061012146 5 4 0.3183208928680043 1387, 1737, 2194, 3030 GO:0005544 MF e calcium-dependent phospholipid binding 3/204 53/19669 0.01761220229818 4 3 0.3183208928680043 302, 311, 5321 GO:0042288 MF e MHC class I protein binding 2/204 20/19669 0.0179889627130527 5 2 0.3183208928680043 7415, 10383 GO:0003677 MF e DNA binding 37/204 2449/19669 0.0184501555234803 4 37 0.3183208928680043 60, 196, 213, 283, 351, 1387, 2023, 2066, 2353, 2521, 3146, 3178, 3181, 3297, 3727, 4137, 4780, 4831, 4851, 5465, 5468, 5591, 6256, 6615, 6622, 6648, 7124, 7157, 8148, 9131, 9971, 10736, 10891, 23064, 23435, 136319, 170825 GO:0004869 MF e cysteine-type endopeptidase inhibitor activity 3/204 54/19669 0.0185088296393289 6 3 0.3183208928680043 331, 1471, 6622 GO:0046982 MF e protein heterodimerization activity 8/204 321/19669 0.0191478823283956 4 8 0.3183208928680043 196, 581, 598, 3297, 3654, 5154, 7157, 9217 GO:0001099 MF e basal RNA polymerase II transcription machinery binding 3/204 55/19669 0.0194304012901086 4 3 0.3183208928680043 196, 7157, 23476 GO:0001098 MF e basal transcription machinery binding 3/204 55/19669 0.0194304012901086 3 3 0.3183208928680043 196, 7157, 23476 GO:0043027 MF e cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/204 21/19669 0.0197484414573935 7 2 0.3183208928680043 331, 6622 GO:0070530 MF e K63-linked polyubiquitin modification-dependent protein binding 2/204 21/19669 0.0197484414573935 5 2 0.3183208928680043 8878, 10133 GO:0120020 MF e cholesterol transfer activity 2/204 21/19669 0.0197484414573935 5 2 0.3183208928680043 335, 348 GO:0004497 MF e monooxygenase activity 4/204 100/19669 0.0203566825186813 3 4 0.3183208928680043 1559, 1571, 2326, 4846 GO:0043621 MF e protein self-association 3/204 56/19669 0.0203769487838629 3 3 0.3183208928680043 3297, 5468, 7157 GO:0005509 MF e calcium ion binding 14/204 705/19669 0.0203770865980833 5 14 0.3183208928680043 302, 311, 794, 821, 1401, 2934, 3309, 3949, 4851, 5321, 5444, 6622, 9104, 23025 GO:0120015 MF e sterol transfer activity 2/204 22/19669 0.0215769005811692 4 2 0.3285636367344068 335, 348 GO:0004602 MF e glutathione peroxidase activity 2/204 22/19669 0.0215769005811692 5 2 0.3285636367344068 2876, 2950 GO:0140359 MF e ABC-type transporter activity 2/204 22/19669 0.0215769005811692 9 2 0.3285636367344068 1244, 5243 GO:0005158 MF e insulin receptor binding 2/204 22/19669 0.0215769005811692 4 2 0.3285636367344068 3479, 6464 GO:1990841 MF e promoter-specific chromatin binding 3/204 58/19669 0.0223450484643384 3 3 0.3380933925288923 3297, 7157, 10891 GO:0097110 MF e scaffold protein binding 3/204 58/19669 0.0223450484643384 3 3 0.3380933925288923 7431, 11315, 54209 GO:1902936 MF e phosphatidylinositol bisphosphate binding 4/204 104/19669 0.0231279341468691 6 4 0.3488279845453181 302, 2934, 4137, 5216 GO:0001786 MF e phosphatidylserine binding 3/204 59/19669 0.0233666155343687 4 3 0.3513126278600814 302, 3146, 26762 GO:0070840 MF e dynein complex binding 2/204 23/19669 0.0234727347404005 3 2 0.3517948351786851 4744, 6622 GO:0001221 MF e transcription coregulator binding 3/204 61/19669 0.0254847529432689 4 3 0.3795550508886232 196, 4780, 5465 GO:0019207 MF e kinase regulator activity 6/204 218/19669 0.02642822008559 3 6 0.3923764800832442 899, 2950, 3146, 3627, 6622, 57679 GO:0030145 MF e manganese ion binding 3/204 62/19669 0.0265812844956917 6 3 0.3934195720842104 383, 4199, 6648 GO:0008047 MF e enzyme activator activity 11/204 533/19669 0.0272212743699846 3 11 0.4016406041360162 335, 348, 350, 351, 834, 2664, 3146, 5580, 7415, 11315, 57679 GO:0070330 MF e aromatase activity 2/204 25/19669 0.0274602344075504 5 2 0.4039119927872205 1559, 1571 GO:0003707 MF e steroid hormone receptor activity 2/204 26/19669 0.0295488157826381 3 2 0.4144662594933046 5465, 6256 GO:0001223 MF e transcription coactivator binding 2/204 26/19669 0.0295488157826381 5 2 0.4144662594933046 196, 5465 GO:0042974 MF e retinoic acid receptor binding 2/204 26/19669 0.0295488157826381 7 2 0.4144662594933046 5468, 9971 GO:0001664 MF e G protein-coupled receptor binding 7/204 287/19669 0.0304978889210151 4 7 0.4144662594933046 183, 3627, 5071, 5179, 6347, 7476, 729230 GO:0043565 MF e sequence-specific DNA binding 26/204 1665/19669 0.0316106115258565 5 26 0.4242255323586237 196, 351, 2023, 2066, 2353, 3146, 3178, 3181, 3297, 3727, 4137, 4780, 5465, 5468, 6256, 6615, 6622, 7124, 7157, 9971, 10736, 10891, 23064, 23435, 136319, 170825 GO:0046875 MF e ephrin receptor binding 2/204 27/19669 0.0316986032387521 4 2 0.4242255323586237 2043, 6464 GO:0005518 MF e collagen binding 3/204 68/19669 0.0336824409850358 3 3 0.4487394390610467 4318, 5154, 7450 GO:1901981 MF e phosphatidylinositol phosphate binding 5/204 172/19669 0.0337572831268605 5 5 0.4487394390610467 302, 2934, 4137, 5216, 5321 GO:0051787 MF e misfolded protein binding 2/204 28/19669 0.0339081158962146 3 2 0.4487394390610467 1191, 3309 GO:0016645 MF e oxidoreductase activity, acting on the CH-NH group of donors 2/204 28/19669 0.0339081158962146 3 2 0.4487394390610467 1719, 4524 GO:0042379 MF e chemokine receptor binding 3/204 69/19669 0.0349524099012278 5 3 0.4612747206687035 3627, 6347, 729230 GO:0016616 MF e oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/204 119/19669 0.0354912889327813 4 4 0.4670889576721441 2194, 3030, 4199, 6652 GO:0005343 MF e organic acid:sodium symporter activity 2/204 29/19669 0.0361758967544485 9 2 0.4734757175768178 6506, 6529 GO:0042910 MF e xenobiotic transmembrane transporter activity 2/204 29/19669 0.0361758967544485 3 2 0.4734757175768178 1244, 5243 GO:0017022 MF e myosin binding 3/204 71/19669 0.0375657484304249 4 3 0.4903155791015084 2934, 4336, 54822 GO:0031210 MF e phosphatidylcholine binding 2/204 30/19669 0.0385005123473097 4 2 0.4980089859136744 335, 5130 GO:0050997 MF e quaternary ammonium group binding 2/204 30/19669 0.0385005123473097 2 2 0.4980089859136744 335, 5130 GO:0051721 MF e protein phosphatase 2A binding 2/204 31/19669 0.0408805524113519 6 2 0.4980089859136744 4137, 7157 GO:0016417 MF e S-acyltransferase activity 2/204 32/19669 0.0433146295730604 5 2 0.5249688905653317 1737, 2194 GO:0001530 MF e lipopolysaccharide binding 2/204 32/19669 0.0433146295730604 3 2 0.5249688905653317 3146, 54209 GO:0003725 MF e double-stranded RNA binding 3/204 76/19669 0.0445226033617738 5 3 0.5382363576890274 3146, 7431, 10383 GO:0016614 MF e oxidoreductase activity, acting on CH-OH group of donors 4/204 129/19669 0.0454982478253232 3 4 0.5481167550221531 2194, 3030, 4199, 6652 GO:0019956 MF e chemokine binding 2/204 33/19669 0.0458013790241622 4 2 0.5481167550221531 3146, 729230 GO:0042287 MF e MHC protein binding 2/204 33/19669 0.0458013790241622 4 2 0.5481167550221531 7415, 10383 GO:0031624 MF e ubiquitin conjugating enzyme binding 2/204 33/19669 0.0458013790241622 5 2 0.5481167550221531 5071, 5465 GO:0035258 MF e steroid hormone receptor binding 3/204 77/19669 0.0459856695555476 7 3 0.5489394875839374 5468, 10891, 11315 GO:0019887 MF e protein kinase regulator activity 5/204 188/19669 0.0464902137895755 4 5 0.5535714428929156 899, 3146, 3627, 6622, 57679 GO:0015248 MF e sterol transporter activity 2/204 34/19669 0.0483394582085962 3 2 0.5727201145861366 335, 348 GO:0016712 MF e oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/204 34/19669 0.0483394582085962 4 2 0.5727201145861366 1559, 1571 GO:0005546 MF e phosphatidylinositol-4,5-bisphosphate binding 3/204 80/19669 0.0505159470908529 7 3 0.5746300602527583 302, 2934, 5216 GO:0001103 MF e RNA polymerase II repressing transcription factor binding 2/204 35/19669 0.050927546506814 6 2 0.5747191768500554 5465, 5468 GO:0042162 MF e telomeric DNA binding 2/204 36/19669 0.0535643449401515 6 2 0.597380757771502 3178, 3181 GO:0043014 MF e alpha-tubulin binding 2/204 36/19669 0.0535643449401515 5 2 0.597380757771502 6622, 10891 GO:0043394 MF e proteoglycan binding 2/204 36/19669 0.0535643449401515 3 2 0.597380757771502 348, 3075 GO:0000217 MF e DNA secondary structure binding 2/204 36/19669 0.0535643449401515 5 2 0.597380757771502 3146, 4137 GO:0016787 MF e hydrolase activity 35/204 2484/19669 0.0561068045982238 2 35 0.6235179526165145 283, 383, 834, 847, 1244, 1509, 1510, 1639, 1804, 2052, 2081, 2180, 2194, 3162, 3309, 3797, 3798, 4313, 4318, 5243, 5321, 5327, 5444, 5445, 5446, 5663, 7277, 7415, 7846, 9104, 9896, 10383, 11315, 23064, 51163 GO:0008395 MF e steroid hydroxylase activity 2/204 37/19669 0.056248575853471 4 2 0.6235179526165145 1559, 1571 GO:0140110 MF e transcription regulator activity 28/204 1905/19669 0.0563016631598578 1 28 0.6235179526165145 196, 1387, 2023, 2130, 2353, 2521, 3146, 3297, 3727, 4780, 4831, 4851, 5071, 5465, 5468, 6256, 6615, 7090, 7157, 8148, 9971, 10736, 10891, 11035, 11315, 23476, 26039, 170825 GO:0048487 MF e beta-tubulin binding 2/204 38/19669 0.0589789826221884 5 2 0.6402868647041451 3064, 9217 GO:0030246 MF e carbohydrate binding 6/204 266/19669 0.0593122237354339 2 6 0.6402868647041451 229, 682, 821, 5836, 6652, 6888 GO:0004857 MF e enzyme inhibitor activity 8/204 377/19669 0.0623240988474119 3 8 0.6565449969491218 183, 302, 331, 335, 351, 1471, 4851, 6622 GO:0001046 MF e core promoter sequence-specific DNA binding 2/204 40/19669 0.0645734006318328 8 2 0.6787350141633581 2353, 7157 GO:0003730 MF e mRNA 3'-UTR binding 3/204 89/19669 0.065341376498725 6 3 0.685291125265878 3181, 7157, 23435 GO:0005506 MF e iron ion binding 4/204 147/19669 0.0670688482344898 6 4 0.7018592466124701 1559, 1571, 3934, 6622 GO:0030331 MF e estrogen receptor binding 2/204 41/19669 0.0674350011441376 8 2 0.7041399789797758 5468, 10891 GO:0000287 MF e magnesium ion binding 5/204 214/19669 0.072533943053037 5 5 0.7332101349893172 2023, 2081, 4217, 6622, 26061 GO:0030159 MF e signaling receptor complex adaptor activity 2/204 43/19669 0.0732811078439852 4 2 0.7391901133052526 6464, 27040 GO:0046943 MF e carboxylic acid transmembrane transporter activity 4/204 152/19669 0.073855529038967 6 4 0.7434059713223143 1244, 5243, 6506, 6529 GO:0005342 MF e organic acid transmembrane transporter activity 4/204 153/19669 0.0752532837654887 5 4 0.7558738925366538 1244, 5243, 6506, 6529 GO:0001784 MF e phosphotyrosine residue binding 2/204 44/19669 0.0762633217034712 5 2 0.7627937713961935 5216, 6464 GO:1904315 MF e transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 2/204 44/19669 0.0762633217034712 10 2 0.7627937713961935 2554, 2892 GO:0004867 MF e serine-type endopeptidase inhibitor activity 3/204 96/19669 0.0780922349774611 6 3 0.7713062399951983 183, 302, 351 GO:0051020 MF e GTPase binding 5/204 219/19669 0.0782997755894916 4 5 0.7713062399951983 2023, 6647, 10133, 57679, 203228 GO:0120013 MF e lipid transfer activity 2/204 45/19669 0.0792834796020517 3 2 0.7713062399951983 335, 348 GO:0140296 MF e general transcription initiation factor binding 2/204 45/19669 0.0792834796020517 4 2 0.7713062399951983 196, 7157 GO:0004715 MF e non-membrane spanning protein tyrosine kinase activity 2/204 46/19669 0.0823404828661548 7 2 0.7903022911052555 3718, 5580 GO:0048020 MF e CCR chemokine receptor binding 2/204 46/19669 0.0823404828661548 6 2 0.7903022911052555 6347, 729230 GO:0003682 MF e chromatin binding 10/204 552/19669 0.0828141424518831 2 10 0.7932459491711632 60, 1387, 2353, 2521, 3297, 4851, 5468, 7157, 10891, 23476 GO:0016747 MF e transferase activity, transferring acyl groups other than amino-acyl groups 5/204 224/19669 0.0843054131007295 4 5 0.8059054680916821 1387, 1737, 2194, 3030, 5321 GO:0005319 MF e lipid transporter activity 4/204 160/19669 0.0854078331764826 2 4 0.8134135809891245 335, 348, 5243, 6506 GO:0099529 MF e neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/204 47/19669 0.0854332512973212 5 2 0.8134135809891245 2554, 2892 GO:0016651 MF e oxidoreductase activity, acting on NAD(P)H 3/204 102/19669 0.0898166194399159 3 3 0.8399975570059857 2936, 9131, 50507 GO:0008009 MF e chemokine activity 2/204 49/19669 0.0917218539272234 6 2 0.8544520157024285 3627, 6347 GO:0098632 MF e cell-cell adhesion mediator activity 2/204 49/19669 0.0917218539272234 5 2 0.8544520157024285 302, 682 GO:0140096 MF e catalytic activity, acting on a protein 31/204 2227/19669 0.0943663360189056 2 31 0.8773668540622718 331, 834, 1387, 1509, 1510, 1737, 1804, 2043, 2066, 2081, 3654, 3718, 4217, 4313, 4318, 4750, 4831, 5071, 5166, 5327, 5580, 5591, 5663, 6347, 8878, 11035, 11315, 23476, 29110, 54822, 57172 GO:0047485 MF e protein N-terminus binding 3/204 106/19669 0.0980171147313771 3 3 0.8893880986799388 7157, 7450, 23256 GO:0004540 MF e ribonuclease activity 3/204 107/19669 0.1001132883839827 5 3 0.897430628513777 283, 2081, 51163 GO:0001085 MF e RNA polymerase II transcription factor binding 2/204 53/19669 0.1046827068574796 5 2 0.9348637975185822 1387, 7157 GO:0051287 MF e NAD binding 2/204 53/19669 0.1046827068574796 5 2 0.9348637975185822 4199, 6652 GO:0016597 MF e amino acid binding 2/204 54/19669 0.1079970867474711 5 2 0.9430492319137244 4846, 83667 GO:0070279 MF e vitamin B6 binding 2/204 54/19669 0.1079970867474711 4 2 0.9430492319137244 213, 5836 GO:0030170 MF e pyridoxal phosphate binding 2/204 54/19669 0.1079970867474711 5 2 0.9430492319137244 213, 5836 GO:0050840 MF e extracellular matrix binding 2/204 55/19669 0.1113392258202733 2 2 0.9670432575358662 6696, 7422 GO:0000149 MF e SNARE binding 3/204 113/19669 0.1130600402873593 3 3 0.9801975390606644 6622, 23025, 23256 GO:0008236 MF e serine-type peptidase activity 4/204 178/19669 0.1143603578782257 4 4 0.9896649549716772 1804, 4313, 4318, 5327 GO:0045309 MF e protein phosphorylated amino acid binding 2/204 56/19669 0.1147081990455053 4 2 0.9908702793912648 5216, 6464 GO:0017171 MF e serine hydrolase activity 4/204 180/19669 0.1178157628845196 3 4 0.9959834332105924 1804, 4313, 4318, 5327 GO:0005262 MF e calcium channel activity 3/204 116/19669 0.1197609161011365 8 3 1.0 302, 5663, 54822 GO:0042626 MF e ATPase-coupled transmembrane transporter activity 2/204 58/19669 0.1215230277351575 8 2 1.0 1244, 5243 GO:0098631 MF e cell adhesion mediator activity 2/204 58/19669 0.1215230277351575 4 2 1.0 302, 682 GO:0016667 MF e oxidoreductase activity, acting on a sulfur group of donors 2/204 58/19669 0.1215230277351575 3 2 1.0 2936, 83667 GO:0004519 MF e endonuclease activity 3/204 118/19669 0.124308236565451 5 3 1.0 283, 2081, 51163 GO:0022824 MF e transmitter-gated ion channel activity 2/204 59/19669 0.1249671123711513 9 2 1.0 2554, 2892 GO:0022835 MF e transmitter-gated channel activity 2/204 59/19669 0.1249671123711513 7 2 1.0 2554, 2892 GO:0003729 MF e mRNA binding 6/204 290/19669 0.1296958795461039 5 6 1.0 1719, 3181, 7157, 9782, 11315, 23435 GO:0031267 MF e small GTPase binding 4/204 187/19669 0.1302604195948823 5 4 1.0 6647, 10133, 57679, 203228 GO:0004714 MF e transmembrane receptor protein tyrosine kinase activity 2/204 61/19669 0.1319243106109939 7 2 1.0 2043, 2066 GO:0004521 MF e endoribonuclease activity 2/204 61/19669 0.1319243106109939 6 2 1.0 2081, 51163 GO:0015399 MF e primary active transmembrane transporter activity 2/204 61/19669 0.1319243106109939 4 2 1.0 1244, 5243 GO:0098960 MF e postsynaptic neurotransmitter receptor activity 2/204 62/19669 0.1354357448241208 4 2 1.0 2554, 2892 GO:0003774 MF e motor activity 3/204 127/19669 0.1455104903401019 7 3 1.0 1639, 3797, 3798 GO:0017124 MF e SH3 domain binding 3/204 127/19669 0.1455104903401019 4 3 1.0 2876, 4137, 5071 GO:0003684 MF e damaged DNA binding 2/204 65/19669 0.1460916199509342 5 2 1.0 1387, 3146 GO:0005085 MF e guanyl-nucleotide exchange factor activity 4/204 196/19669 0.1470210680958203 5 4 1.0 7074, 57679, 64283, 203228 GO:0005516 MF e calmodulin binding 4/204 198/19669 0.15085527952193 3 4 1.0 2130, 4846, 23025, 57172 GO:0016887 MF e ATPase activity 8/204 466/19669 0.1568424716507309 7 8 1.0 1244, 2180, 3309, 3797, 3798, 5243, 7415, 23064 GO:0003777 MF e microtubule motor activity 2/204 68/19669 0.1569134345530403 8 2 1.0 3797, 3798 GO:0008028 MF e monocarboxylic acid transmembrane transporter activity 2/204 68/19669 0.1569134345530403 7 2 1.0 6506, 6529 GO:0015085 MF e calcium ion transmembrane transporter activity 3/204 132/19669 0.1577689707392073 7 3 1.0 302, 5663, 54822 GO:0003690 MF e double-stranded DNA binding 23/204 1656/19669 0.1611332070487565 5 23 1.0 196, 351, 2023, 2066, 2353, 3146, 3297, 3727, 4137, 4780, 5465, 5468, 5591, 6256, 6615, 6622, 7124, 7157, 9971, 10736, 23064, 23435, 170825 GO:0035591 MF e signaling adaptor activity 2/204 70/19669 0.1642101558621359 3 2 1.0 6464, 27040 GO:0019955 MF e cytokine binding 3/204 136/19669 0.1677973304461729 3 3 1.0 3146, 11315, 729230 GO:0009055 MF e electron transfer activity 3/204 136/19669 0.1677973304461729 3 3 1.0 2936, 4199, 50507 GO:0015370 MF e solute:sodium symporter activity 2/204 72/19669 0.1715659247714317 8 2 1.0 6506, 6529 GO:0005230 MF e extracellular ligand-gated ion channel activity 2/204 73/19669 0.1752642235225978 8 2 1.0 2554, 2892 GO:0019905 MF e syntaxin binding 2/204 76/19669 0.1864327809598713 4 2 1.0 23025, 23256 GO:0016746 MF e transferase activity, transferring acyl groups 5/204 251/19669 0.1925334274722785 3 5 1.0 1387, 1737, 2194, 3030, 5321 GO:0016788 MF e hydrolase activity, acting on ester bonds 11/204 734/19669 0.1933679752001877 3 11 1.0 283, 2081, 2194, 3162, 5321, 5444, 5445, 5446, 9104, 9896, 51163 GO:0015171 MF e amino acid transmembrane transporter activity 2/204 78/19669 0.1939334503354436 7 2 1.0 6506, 6529 GO:0035091 MF e phosphatidylinositol binding 5/204 253/19669 0.1939857849010003 4 5 1.0 302, 2934, 4137, 5216, 5321 GO:0030674 MF e protein-macromolecule adaptor activity 5/204 261/19669 0.2004317895575243 2 5 1.0 4137, 4744, 6464, 10133, 27040 GO:0019199 MF e transmembrane receptor protein kinase activity 2/204 80/19669 0.2014723199278976 6 2 1.0 2043, 2066 GO:0048306 MF e calcium-dependent protein binding 2/204 81/19669 0.2052545914182287 3 2 1.0 302, 311 GO:0043130 MF e ubiquitin binding 2/204 83/19669 0.2128419287927239 4 2 1.0 5071, 8878 GO:0030165 MF e PDZ domain binding 2/204 83/19669 0.2128419287927239 4 2 1.0 5071, 5663 GO:0042562 MF e hormone binding 2/204 84/19669 0.2166458757521485 2 2 1.0 6464, 7276 GO:0008013 MF e beta-catenin binding 2/204 84/19669 0.2166458757521485 3 2 1.0 5071, 5663 GO:0030295 MF e protein kinase activator activity 2/204 84/19669 0.2166458757521485 5 2 1.0 3146, 57679 GO:0051117 MF e ATPase binding 2/204 85/19669 0.2204559467238783 4 2 1.0 229, 5663 GO:0003727 MF e single-stranded RNA binding 2/204 85/19669 0.2204559467238783 5 2 1.0 3146, 3178 GO:0017111 MF e nucleoside-triphosphatase activity 12/204 832/19669 0.2206981433652352 6 12 1.0 1244, 1639, 2180, 3309, 3797, 3798, 5243, 7277, 7415, 7846, 10383, 23064 GO:0004175 MF e endopeptidase activity 7/204 430/19669 0.2209160460390669 4 7 1.0 834, 1509, 1510, 4313, 4318, 5327, 5663 GO:0043178 MF e alcohol binding 2/204 86/19669 0.2242716086984549 3 2 1.0 335, 2733 GO:0001228 MF e DNA-binding transcription activator activity, RNA polymerase II-specific 7/204 442/19669 0.2310532863885966 4 7 1.0 2353, 3727, 4780, 5465, 7157, 9971, 10736 GO:0004252 MF e serine-type endopeptidase activity 3/204 160/19669 0.2312680869884996 5 3 1.0 4313, 4318, 5327 GO:0000976 MF e transcription regulatory region sequence-specific DNA binding 20/204 1502/19669 0.2327313153303143 7 20 1.0 196, 351, 2023, 2066, 2353, 3146, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 6622, 7124, 7157, 9971, 10736, 23064, 23435 GO:0001067 MF e regulatory region nucleic acid binding 20/204 1503/19669 0.2329990429410263 4 20 1.0 196, 351, 2023, 2066, 2353, 3146, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 6622, 7124, 7157, 9971, 10736, 23064, 23435 GO:0001216 MF e DNA-binding transcription activator activity 7/204 446/19669 0.2347114716869619 3 7 1.0 2353, 3727, 4780, 5465, 7157, 9971, 10736 GO:1990837 MF e sequence-specific double-stranded DNA binding 21/204 1565/19669 0.2395610780642851 6 21 1.0 196, 351, 2023, 2066, 2353, 3146, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 6622, 7124, 7157, 9971, 10736, 23064, 23435, 170825 GO:0019209 MF e kinase activator activity 2/204 90/19669 0.2395798633138398 4 2 1.0 3146, 57679 GO:0001227 MF e DNA-binding transcription repressor activity, RNA polymerase II-specific 5/204 306/19669 0.2529243155956421 4 5 1.0 2023, 3297, 5465, 5468, 6615 GO:0001217 MF e DNA-binding transcription repressor activity 5/204 308/19669 0.2557926402726867 3 5 1.0 2023, 3297, 5465, 5468, 6615 GO:0005201 MF e extracellular matrix structural constituent 3/204 170/19669 0.258918347222154 2 3 1.0 2243, 7450, 9370 GO:0015108 MF e chloride transmembrane transporter activity 2/204 99/19669 0.2741595488920643 6 2 1.0 2554, 6529 GO:0015294 MF e solute:cation symporter activity 2/204 99/19669 0.2741595488920643 6 2 1.0 6506, 6529 GO:0005496 MF e steroid binding 2/204 100/19669 0.2780030103020633 3 2 1.0 335, 9971 GO:0032182 MF e ubiquitin-like protein binding 2/204 101/19669 0.2818452198875779 3 2 1.0 5071, 8878 GO:0004620 MF e phospholipase activity 2/204 105/19669 0.2971939452698283 5 2 1.0 3162, 5321 GO:0004222 MF e metalloendopeptidase activity 2/204 107/19669 0.3048511447426776 5 2 1.0 4313, 4318 GO:0008233 MF e peptidase activity 9/204 615/19669 0.3055093328256641 3 9 1.0 834, 1509, 1510, 1804, 4313, 4318, 5327, 5663, 11315 GO:0016462 MF e pyrophosphatase activity 12/204 885/19669 0.3081564640274352 5 12 1.0 1244, 1639, 2180, 3309, 3797, 3798, 5243, 7277, 7415, 7846, 10383, 23064 GO:0016818 MF e hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 12/204 887/19669 0.3091395926113374 4 12 1.0 1244, 1639, 2180, 3309, 3797, 3798, 5243, 7277, 7415, 7846, 10383, 23064 GO:0016817 MF e hydrolase activity, acting on acid anhydrides 12/204 887/19669 0.3091395926113374 3 12 1.0 1244, 1639, 2180, 3309, 3797, 3798, 5243, 7277, 7415, 7846, 10383, 23064 GO:0030594 MF e neurotransmitter receptor activity 2/204 110/19669 0.3163077295054379 3 2 1.0 2554, 2892 GO:0042826 MF e histone deacetylase binding 2/204 114/19669 0.3315151516063596 4 2 1.0 5071, 7157 GO:0016810 MF e hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/204 121/19669 0.3578882859021454 3 2 1.0 383, 847 GO:0060589 MF e nucleoside-triphosphatase regulator activity 7/204 507/19669 0.3746474281616182 3 7 1.0 2664, 5216, 7074, 57679, 64283, 83667, 203228 GO:0016298 MF e lipase activity 2/204 130/19669 0.3912244835304781 4 2 1.0 3162, 5321 GO:0060090 MF e molecular adaptor activity 5/204 324/19669 0.3945589369240996 1 5 1.0 4137, 4744, 6464, 10133, 27040 GO:0008514 MF e organic anion transmembrane transporter activity 3/204 174/19669 0.4317807628240578 5 3 1.0 1244, 6506, 6529 GO:0003714 MF e transcription corepressor activity 3/204 183/19669 0.4425208579307902 3 3 1.0 1387, 5071, 7090 GO:0008022 MF e protein C-terminus binding 3/204 185/19669 0.4451140620809164 3 3 1.0 5468, 6311, 10133 GO:0004518 MF e nuclease activity 3/204 198/19669 0.4635402309471105 4 3 1.0 283, 2081, 51163 GO:0030695 MF e GTPase regulator activity 6/204 464/19669 0.4874276451677745 4 6 1.0 2664, 7074, 57679, 64283, 83667, 203228 GO:0022804 MF e active transmembrane transporter activity 4/204 298/19669 0.5555700771886833 3 4 1.0 1244, 5243, 6506, 6529 GO:0000978 MF e RNA polymerase II cis-regulatory region sequence-specific DNA binding 14/204 1191/19669 0.556740261679595 9 14 1.0 196, 351, 2353, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 7157, 9971, 10736, 23435 GO:0001882 MF e nucleoside binding 5/204 385/19669 0.6044710339416286 3 5 1.0 4831, 4860, 7277, 7846, 10383 GO:0046873 MF e metal ion transmembrane transporter activity 5/204 423/19669 0.6296321463106378 6 5 1.0 302, 5663, 6506, 6529, 54822 GO:0015267 MF e channel activity 6/204 476/19669 0.6418783691931976 4 6 1.0 302, 581, 2554, 2892, 5663, 54822 GO:0022803 MF e passive transmembrane transporter activity 6/204 477/19669 0.6422263610644068 3 6 1.0 302, 581, 2554, 2892, 5663, 54822 GO:0019838 MF e growth factor binding 2/204 137/19669 0.6551287638263273 3 2 1.0 5154, 6464 GO:0015276 MF e ligand-gated ion channel activity 2/204 139/19669 0.6573298188226093 7 2 1.0 2554, 2892 GO:0022834 MF e ligand-gated channel activity 2/204 139/19669 0.6573298188226093 6 2 1.0 2554, 2892 GO:0000987 MF e cis-regulatory region sequence-specific DNA binding 14/204 1210/19669 0.6590571864523342 8 14 1.0 196, 351, 2353, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 7157, 9971, 10736, 23435 GO:0015293 MF e symporter activity 2/204 143/19669 0.6619001615163336 5 2 1.0 6506, 6529 GO:0015103 MF e inorganic anion transmembrane transporter activity 2/204 143/19669 0.6619001615163336 5 2 1.0 2554, 6529 GO:0008528 MF e G protein-coupled peptide receptor activity 2/204 146/19669 0.665462438250987 5 2 1.0 10280, 729230 GO:0015081 MF e sodium ion transmembrane transporter activity 2/204 146/19669 0.665462438250987 7 2 1.0 6506, 6529 GO:0001653 MF e peptide receptor activity 2/204 150/19669 0.6703719516408726 3 2 1.0 10280, 729230 GO:0016874 MF e ligase activity 2/204 165/19669 0.6900534765039456 2 2 1.0 2180, 5091 GO:0008237 MF e metallopeptidase activity 2/204 183/19669 0.7152732532793531 4 2 1.0 4313, 4318 GO:0016757 MF e transferase activity, transferring glycosyl groups 3/204 272/19669 0.7617181018729595 3 3 1.0 4860, 5836, 55830 GO:0016791 MF e phosphatase activity 3/204 274/19669 0.7632047798621401 5 3 1.0 5444, 5446, 9896 GO:0005261 MF e cation channel activity 4/204 333/19669 0.7804166955378865 6 4 1.0 302, 2892, 5663, 54822 GO:0042578 MF e phosphoric ester hydrolase activity 4/204 365/19669 0.7929137508905879 4 4 1.0 3162, 5444, 5446, 9896 GO:0032550 MF e purine ribonucleoside binding 4/204 376/19669 0.7981982100157939 5 4 1.0 4831, 7277, 7846, 10383 GO:0032549 MF e ribonucleoside binding 4/204 379/19669 0.7997092317277443 4 4 1.0 4831, 7277, 7846, 10383 GO:0001883 MF e purine nucleoside binding 4/204 379/19669 0.7997092317277443 4 4 1.0 4831, 7277, 7846, 10383 GO:0005216 MF e ion channel activity 5/204 429/19669 0.8065125317545409 5 5 1.0 302, 2554, 2892, 5663, 54822 GO:0008509 MF e anion transmembrane transporter activity 5/204 452/19669 0.8123920408017152 4 5 1.0 1244, 2554, 5243, 6506, 6529 GO:0015318 MF e inorganic molecular entity transmembrane transporter activity 9/204 818/19669 0.8589984994398943 3 9 1.0 302, 1244, 2554, 2892, 5243, 5663, 6506, 6529, 54822 GO:0000977 MF e RNA polymerase II transcription regulatory region sequence-specific DNA binding 15/204 1408/19669 0.8911326523070083 8 15 1.0 196, 351, 2023, 2353, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 7157, 9971, 10736, 23435 GO:0022890 MF e inorganic cation transmembrane transporter activity 6/204 578/19669 1.0 5 6 1.0 302, 2892, 5663, 6506, 6529, 54822 GO:0004930 MF p G protein-coupled receptor activity 3/204 835/19669 0.0519572118412609 4 3 0.5849495579569449 5468, 10280, 729230 GO:0004888 MF p transmembrane signaling receptor activity 9/204 1262/19669 0.3126955345410083 3 9 1.0 2043, 2066, 2554, 2892, 4851, 5468, 10280, 54209, 729230 GO:0004842 MF p ubiquitin-protein transferase activity 2/204 426/19669 0.3338149407355009 4 2 1.0 331, 5071 GO:0019787 MF p ubiquitin-like protein transferase activity 2/204 448/19669 0.3382888560590765 3 2 1.0 331, 5071 GO:0022836 MF p gated channel activity 2/204 336/19669 0.5901667064903705 5 2 1.0 2554, 2892 GO:0038023 MF p signaling receptor activity 13/204 1454/19669 0.6865141256837708 2 13 1.0 924, 2043, 2066, 2554, 2892, 4851, 5465, 5468, 6256, 9971, 10280, 54209, 729230 GO:0060089 MF p molecular transducer activity 13/204 1454/19669 0.6865141256837708 1 13 1.0 924, 2043, 2066, 2554, 2892, 4851, 5465, 5468, 6256, 9971, 10280, 54209, 729230 GO:0061630 MF p ubiquitin protein ligase activity 2/204 291/19669 0.7731345934247669 5 2 1.0 331, 5071 GO:0061659 MF p ubiquitin-like protein ligase activity 2/204 302/19669 0.7738221348934562 4 2 1.0 331, 5071 GO:0032561 MF p guanyl ribonucleotide binding 4/204 393/19669 1.0 7 4 1.0 4831, 7277, 7846, 10383 GO:0003700 MF p DNA-binding transcription factor activity 14/204 1427/19669 1.0 2 14 1.0 196, 2023, 2353, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 7157, 9971, 10736, 170825 GO:0051015 MF p actin filament binding 2/204 208/19669 1.0 5 2 1.0 2934, 10096 GO:0005525 MF p GTP binding 3/204 371/19669 1.0 8 3 1.0 7277, 7846, 10383 GO:0022853 MF p active ion transmembrane transporter activity 2/204 203/19669 1.0 4 2 1.0 6506, 6529 GO:0015075 MF p ion transmembrane transporter activity 9/204 933/19669 1.0 3 9 1.0 302, 1244, 2554, 2892, 5243, 5663, 6506, 6529, 54822 GO:0019001 MF p guanyl nucleotide binding 4/204 393/19669 1.0 6 4 1.0 4831, 7277, 7846, 10383 GO:0015291 MF p secondary active transmembrane transporter activity 2/204 236/19669 1.0 4 2 1.0 6506, 6529 GO:0042393 MF p histone binding 2/204 239/19669 1.0 3 2 1.0 6622, 23476 GO:0005096 MF p GTPase activator activity 2/204 274/19669 1.0 5 2 1.0 2664, 57679 GO:0000981 MF p DNA-binding transcription factor activity, RNA polymerase II-specific 14/204 1375/19669 1.0 3 14 1.0 196, 2023, 2353, 3297, 3727, 4780, 5465, 5468, 6256, 6615, 7157, 9971, 10736, 170825 GO:0005215 MF p transporter activity 12/204 1157/19669 1.0 1 12 1.0 302, 335, 348, 581, 1244, 2554, 2892, 5243, 5663, 6506, 6529, 54822 GO:0140098 MF p catalytic activity, acting on RNA 3/204 376/19669 1.0 2 3 1.0 283, 2081, 51163 GO:0008324 MF p cation transmembrane transporter activity 6/204 625/19669 1.0 4 6 1.0 302, 2892, 5663, 6506, 6529, 54822 GO:0022857 MF p transmembrane transporter activity 10/204 1048/19669 1.0 2 10 1.0 302, 581, 1244, 2554, 2892, 5243, 5663, 6506, 6529, 54822 GO:0003924 MF p GTPase activity 3/204 317/19669 1.0 7 3 1.0 7277, 7846, 10383